Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase.

Pinheiro, Matheus Pinto; Emery, Flávio da Silva; Nonato, M Cristina

Pinheiro, Matheus Pinto; Emery, Flávio da Silva; Nonato, M Cristina.

Affiliation

Pinheiro MP; Laboratorio de Cristalografia de Proteinas, Departamento de Fisica e Quimica, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, USP., Av. Cafe S/N, Monte Alegre, Ribeirao Preto, S.P. Brazil.

Curr Pharm Des ; 19(14): 2615-27, 2013.

Article in En | MEDLINE | ID: mdl-23116399

Subject(s)

Drug Design; Oxidoreductases Acting on CH-CH Group Donors/antagonists & inhibitors; Oxidoreductases Acting on CH-CH Group Donors/chemistry; Trypanocidal Agents; Amino Acid Sequence; Animals; Dihydroorotate Dehydrogenase; Humans; Models, Molecular; Molecular Sequence Data; Protein Conformation; Pyrimidine Nucleotides/biosynthesis; Sequence Alignment; Structure-Activity Relationship; Trypanocidal Agents/chemistry; Trypanocidal Agents/pharmacology; Trypanocidal Agents/therapeutic use; Trypanosoma/drug effects; Trypanosoma/enzymology; Trypanosomiasis/drug therapy

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Collection: 01-internacional Database: MEDLINE Main subject: Trypanocidal Agents / Drug Design / Oxidoreductases Acting on CH-CH Group Donors Limits: Animals / Humans Language: En Journal: Curr Pharm Des Journal subject: FARMACIA Year: 2013 Document type: Article Country of publication: United Arab Emirates

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