Structural modifications of a 3-methoxy-2-aminopyridine compound to reduce potential for mutagenicity and time-dependent drug-drug interaction.

Palmer, Cynthia; Pairish, Mason; Kephart, Susan; Bouzida, Djamal; Cui, Jingrong; Deal, Judith; Dong, Liming; Gu, Danlin; Linton, Angelica; McAlpine, Indrawan; Yamazaki, Shinji; Smith, Evan; John-Baptiste, Annette; Bagrodia, Shubha; Kania, Robert; Guo, Chuangxing

Palmer, Cynthia; Pairish, Mason; Kephart, Susan; Bouzida, Djamal; Cui, Jingrong; Deal, Judith; Dong, Liming; Gu, Danlin; Linton, Angelica; McAlpine, Indrawan; Yamazaki, Shinji; Smith, Evan; John-Baptiste, Annette; Bagrodia, Shubha; Kania, Robert; Guo, Chuangxing.

Affiliation

Palmer C; Oncology Medicinal Chemistry, Pfizer PharmaTherapeutics R&D, San Diego, CA 92121, USA. cindy.palmer@pfizer.com

Bioorg Med Chem Lett ; 22(24): 7605-9, 2012 Dec 15.

Article in En | MEDLINE | ID: mdl-23116892

Subject(s)

Aminopyridines/chemistry; Aminopyridines/metabolism; Electrons; Humans; Microsomes, Liver/chemistry; Microsomes, Liver/metabolism; Molecular Structure; Mutagenicity Tests; Oxidation-Reduction; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aminopyridines Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United kingdom

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