Genotoxicity of alcohol is linked to DNA replication-associated damage and homologous recombination repair.

Kotova, Natalia; Vare, Daniel; Schultz, Niklas; Gradecka Meesters, Dobroslawa; Stepnik, Maciej; Grawé, Jan; Helleday, Thomas; Jenssen, Dag

Kotova, Natalia; Vare, Daniel; Schultz, Niklas; Gradecka Meesters, Dobroslawa; Stepnik, Maciej; Grawé, Jan; Helleday, Thomas; Jenssen, Dag.

Affiliation

Kotova N; Department of Genetics, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.

Carcinogenesis ; 34(2): 325-30, 2013 Feb.

Article in En | MEDLINE | ID: mdl-23125219

Subject(s)

Acetaldehyde/toxicity; Alcohols/toxicity; DNA Breaks, Double-Stranded/drug effects; DNA Replication/drug effects; Recombination, Genetic/drug effects; Recombinational DNA Repair/drug effects; Animals; CHO Cells; Cells, Cultured; Cricetinae; Fibroblasts/cytology; Fibroblasts/drug effects; Fibroblasts/metabolism; Genomic Instability/drug effects; Lung/cytology; Lung/drug effects; Lung/metabolism; Male; Micronucleus Tests; Rad51 Recombinase/metabolism; Rats; Rats, Wistar

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombination, Genetic / DNA Replication / Alcohols / DNA Breaks, Double-Stranded / Recombinational DNA Repair / Acetaldehyde Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Carcinogenesis Year: 2013 Document type: Article Affiliation country: Sweden Country of publication: United kingdom

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