Niclosamide is a proton carrier and targets acidic endosomes with broad antiviral effects.

Jurgeit, Andreas; McDowell, Robert; Moese, Stefan; Meldrum, Eric; Schwendener, Reto; Greber, Urs F

Jurgeit, Andreas; McDowell, Robert; Moese, Stefan; Meldrum, Eric; Schwendener, Reto; Greber, Urs F.

Affiliation

Jurgeit A; Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.

PLoS Pathog ; 8(10): e1002976, 2012.

Article in En | MEDLINE | ID: mdl-23133371

Subject(s)

Antiviral Agents/pharmacology; Endosomes/drug effects; Niclosamide/pharmacology; Orthomyxoviridae/drug effects; Rhinovirus/drug effects; Virus Internalization/drug effects; Antinematodal Agents/pharmacology; Coated Vesicles/drug effects; Drug Synergism; Endosomes/physiology; HeLa Cells; Humans; Hydrogen-Ion Concentration; Liposomes; Macrolides/pharmacology; Niclosamide/chemistry; Orthomyxoviridae/physiology; RNA Virus Infections/drug therapy; RNA Virus Infections/prevention & control; Rhinovirus/physiology; Structure-Activity Relationship; Virus Replication/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Orthomyxoviridae / Endosomes / Rhinovirus / Virus Internalization / Niclosamide Limits: Humans Language: En Journal: PLoS Pathog Year: 2012 Document type: Article Affiliation country: Switzerland Country of publication: United States

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