Enhanced costimulation by CD70+ B cells aggravates experimental autoimmune encephalomyelitis in autoimmune mice.
J Neuroimmunol
; 255(1-2): 8-17, 2013 Feb 15.
Article
in En
| MEDLINE
| ID: mdl-23137837
ABSTRACT
OBJECTIVE:
Assess whether CD70+ B cells contribute to EAE. MATERIALS ANDMETHODS:
MOG-specific TCR transgenic mice (2D2) were crossed with mice with constitutive CD70 expression on B cells. The development of EAE and the phenotype of B-T lymphocytes were studied in 2D2xCD70 animals.RESULTS:
Spontaneous EAE developed in 20% of 2D2xCD70 and 3% of 2D2 mice. EAE was also more severe in 2D2xCD70 versus 2D2 animals upon MOG immunization. The susceptibility of 2D2xCD70 to EAE was associated with fewer FoxP3+ T cells.CONCLUSIONS:
Expression of CD70 by B cells aggravates EAE possibly by reducing the number of regulatory T cells.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
B-Lymphocyte Subsets
/
Encephalomyelitis, Autoimmune, Experimental
/
CD27 Ligand
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
J Neuroimmunol
Year:
2013
Document type:
Article
Affiliation country:
Netherlands