KR-31543 reduces the production of proinflammatory molecules in human endothelial cells and monocytes and attenuates atherosclerosis in mouse model.

Choi, Jae-Hoon; Yoo, Ji-Young; Kim, Sun-Ok; Yoo, Sung-Eun; Oh, Goo Taeg

Choi, Jae-Hoon; Yoo, Ji-Young; Kim, Sun-Ok; Yoo, Sung-Eun; Oh, Goo Taeg.

Affiliation

Choi JH; Laboratory of Molecular Physiology, Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul 133-791, Kore.

Exp Mol Med ; 44(12): 733-9, 2012 Dec 31.

Article in En | MEDLINE | ID: mdl-23143639

Subject(s)

Atherosclerosis/drug therapy; Benzopyrans/pharmacology; Inflammation Mediators/metabolism; Monocytes/metabolism; Neuroprotective Agents/pharmacology; Tetrazoles/pharmacology; Animals; Aorta/pathology; Atherosclerosis/blood; Atherosclerosis/pathology; Benzopyrans/therapeutic use; Cholesterol, HDL/blood; Cholesterol, LDL/blood; Diet; Disease Models, Animal; Human Umbilical Vein Endothelial Cells/drug effects; Human Umbilical Vein Endothelial Cells/metabolism; Interleukin-6/metabolism; Interleukin-8/metabolism; Macrophages/metabolism; Mice; Mice, Transgenic; Monocytes/drug effects; Neuroprotective Agents/therapeutic use; Receptors, CCR2/metabolism; Receptors, LDL/genetics; Tetrazoles/therapeutic use; Transendothelial and Transepithelial Migration/drug effects; Triglycerides/blood; Vascular Cell Adhesion Molecule-1/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tetrazoles / Benzopyrans / Monocytes / Neuroprotective Agents / Inflammation Mediators / Atherosclerosis Type of study: Prognostic_studies Limits: Animals Language: En Journal: Exp Mol Med Journal subject: BIOLOGIA MOLECULAR / BIOQUIMICA Year: 2012 Document type: Article Country of publication: United States

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