Identification of novel mPGES-1 inhibitors through screening of a chemical library.

Park, Sung-Jun; Han, Seong-Gu; Ahsan, Hafiz Muhammad; Lee, Kijae; Lee, Jae Yeol; Shin, Ji-Sun; Lee, Kyung-Tae; Kang, Nam-Suk; Yu, Yeon Gyu

Park, Sung-Jun; Han, Seong-Gu; Ahsan, Hafiz Muhammad; Lee, Kijae; Lee, Jae Yeol; Shin, Ji-Sun; Lee, Kyung-Tae; Kang, Nam-Suk; Yu, Yeon Gyu.

Affiliation

Park SJ; Department of Chemistry, Kookmin University, 861-1 Jeongneung-dong, Seongbuk-gu, Seoul 136-702, Republic of Korea.

Bioorg Med Chem Lett ; 22(24): 7335-9, 2012 Dec 15.

Article in En | MEDLINE | ID: mdl-23147075

Subject(s)

Enzyme Inhibitors/analysis; Enzyme Inhibitors/pharmacology; High-Throughput Screening Assays; Intramolecular Oxidoreductases/antagonists & inhibitors; Small Molecule Libraries/analysis; Small Molecule Libraries/pharmacology; Animals; Binding Sites/drug effects; Cell Line; Dinoprostone/antagonists & inhibitors; Dinoprostone/biosynthesis; Dose-Response Relationship, Drug; Enzyme Inhibitors/chemistry; Humans; Intramolecular Oxidoreductases/metabolism; Lipopolysaccharides/antagonists & inhibitors; Lipopolysaccharides/pharmacology; Mice; Models, Molecular; Molecular Structure; Prostaglandin-E Synthases; Small Molecule Libraries/chemistry; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Intramolecular Oxidoreductases / Enzyme Inhibitors / Small Molecule Libraries / High-Throughput Screening Assays Type of study: Diagnostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article Country of publication: United kingdom

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