Defective FGF signaling causes coloboma formation and disrupts retinal neurogenesis.

Chen, Shuyi; Li, Hua; Gaudenz, Karin; Paulson, Ariel; Guo, Fengli; Trimble, Rhonda; Peak, Allison; Seidel, Christopher; Deng, Chuxia; Furuta, Yasuhide; Xie, Ting

Chen, Shuyi; Li, Hua; Gaudenz, Karin; Paulson, Ariel; Guo, Fengli; Trimble, Rhonda; Peak, Allison; Seidel, Christopher; Deng, Chuxia; Furuta, Yasuhide; Xie, Ting.

Affiliation

Chen S; Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA. sch@stowers.org

Cell Res ; 23(2): 254-73, 2013 Feb.

Article in En | MEDLINE | ID: mdl-23147794

Subject(s)

Coloboma/metabolism; Fibroblast Growth Factors/metabolism; Retina/cytology; Signal Transduction; Animals; Coloboma/pathology; Gene Expression Profiling; Mice; Mice, Knockout; Neurogenesis; Receptor, Fibroblast Growth Factor, Type 1/deficiency; Receptor, Fibroblast Growth Factor, Type 1/genetics; Receptor, Fibroblast Growth Factor, Type 1/metabolism; Receptor, Fibroblast Growth Factor, Type 2/deficiency; Receptor, Fibroblast Growth Factor, Type 2/genetics; Receptor, Fibroblast Growth Factor, Type 2/metabolism; Retinal Ganglion Cells/cytology; Retinal Ganglion Cells/metabolism; Stem Cells/cytology; Stem Cells/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retina / Signal Transduction / Coloboma / Fibroblast Growth Factors Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: Cell Res Year: 2013 Document type: Article Affiliation country: United States

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