Plasmid IL-12 electroporation in melanoma.
Hum Vaccin Immunother
; 8(11): 1734-8, 2012 Nov 01.
Article
in En
| MEDLINE
| ID: mdl-23151447
ABSTRACT
Intratumoral gene electroporation uses electric charges to facilitate entry of plasmid DNA into cells in a reproducible and highly efficient manner, especially to accessible sites such as cutaneous and subcutaneous melanomas. Effective for locally treated disease, electroporation of plasmid DNA encoding interleukin-12 can also induce responses in untreated distant disease, suggesting that adaptive immune responses are being elicited that can target melanoma-associated antigens. In vivo electroporation with immunomodulatory cytokine DNA is a promising approach that can trigger systemic anti-tumor immune responses without the systemic toxicity associated with intravenous cytokine delivery and potentially offer complete long-term tumor regression.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Electroporation
/
Interleukin-12
/
Melanoma
Limits:
Animals
/
Humans
Language:
En
Journal:
Hum Vaccin Immunother
Year:
2012
Document type:
Article
Affiliation country:
United States