Proteasome inhibition upregulates Bim and induces caspase-3-dependent apoptosis in human mast cells expressing the Kit D816V mutation.

Westerberg, C Möller; Hägglund, H; Nilsson, G

Westerberg, C Möller; Hägglund, H; Nilsson, G.

Affiliation

Westerberg CM; Department of Medicine, Karolinska Institutet, Stockholm, Sweden. Christine.Moller@ki.se

Cell Death Dis ; 3: e417, 2012 Nov 15.

Article in En | MEDLINE | ID: mdl-23152053

Subject(s)

Apoptosis Regulatory Proteins/metabolism; Apoptosis; Caspase 3/metabolism; Mast Cells/cytology; Mastocytosis, Systemic/metabolism; Membrane Proteins/metabolism; Mutation, Missense; Proteasome Endopeptidase Complex/metabolism; Proto-Oncogene Proteins c-kit/genetics; Proto-Oncogene Proteins/metabolism; Apoptosis Regulatory Proteins/genetics; Bcl-2-Like Protein 11; Caspase 3/genetics; Cell Line; Down-Regulation; Humans; Mast Cells/enzymology; Mast Cells/metabolism; Mastocytosis, Systemic/enzymology; Mastocytosis, Systemic/genetics; Mastocytosis, Systemic/physiopathology; Membrane Proteins/genetics; Phosphorylation; Proteasome Endopeptidase Complex/genetics; Proteolysis; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins c-kit/metabolism; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins / Apoptosis / Proto-Oncogene Proteins c-kit / Mutation, Missense / Mastocytosis, Systemic / Proteasome Endopeptidase Complex / Apoptosis Regulatory Proteins / Caspase 3 / Mast Cells / Membrane Proteins Limits: Humans Language: En Journal: Cell Death Dis Year: 2012 Document type: Article Affiliation country: Sweden

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