Interleukin-8 stimulates progesterone production via the MEK pathway in ovarian theca cells.
Mol Cell Biochem
; 374(1-2): 157-61, 2013 Feb.
Article
in En
| MEDLINE
| ID: mdl-23160800
ABSTRACT
Interleukin 8 (IL-8) is a chemoattractant associated with ovulation in the mammalian ovary. This chemokine is also involved in the recruitment and activation of neutrophils. Using bovine tissue, we examined the possible role of IL-8 in steroid production by theca cells of the large ovarian follicles. IL-8 promoted progesterone production and stimulated StAR expression in cultured theca cells. The inhibitor of p38 did not disturb the P4 production and StAR expression in IL-8-treated theca cells. On the other hand, the inhibitor of MEK disturbed the P4 production and expression of StAR in theca cells treated with IL-8. These results suggest that IL-8 is associated with progesterone production in bovine theca cells via the MEK pathway.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Progesterone
/
Theca Cells
/
Interleukin-8
/
Mitogen-Activated Protein Kinase Kinases
Limits:
Animals
Language:
En
Journal:
Mol Cell Biochem
Year:
2013
Document type:
Article
Affiliation country:
Japan