Detrimental effects of proteasome inhibition activity in Drosophila melanogaster: implication of ER stress, autophagy, and apoptosis.

Velentzas, Panagiotis D; Velentzas, Athanassios D; Mpakou, Vassiliki E; Antonelou, Marianna H; Margaritis, Lukas H; Papassideri, Issidora S; Stravopodis, Dimitrios J

Velentzas, Panagiotis D; Velentzas, Athanassios D; Mpakou, Vassiliki E; Antonelou, Marianna H; Margaritis, Lukas H; Papassideri, Issidora S; Stravopodis, Dimitrios J.

Affiliation

Velentzas PD; Department of Cell Biology and Biophysics, University of Athens, Panepistimiopolis, Zografou, Athens, Greece. panosvel@biol.uoa.gr

Cell Biol Toxicol ; 29(1): 13-37, 2013 Feb.

Article in En | MEDLINE | ID: mdl-23161111

Subject(s)

Apoptosis/drug effects; Autophagy/drug effects; Boronic Acids/toxicity; Drosophila melanogaster/drug effects; Endoplasmic Reticulum Stress/drug effects; Proteasome Inhibitors/toxicity; Pyrazines/toxicity; Animals; Animals, Genetically Modified; Apoptosis/physiology; Autophagy/physiology; Behavior, Animal/drug effects; Bortezomib; Drosophila melanogaster/enzymology; Endoplasmic Reticulum Stress/physiology; Female; Kaplan-Meier Estimate; Larva/drug effects; Larva/growth & development; Longevity/drug effects; Male; Motor Activity/drug effects; Ovarian Follicle/drug effects; Ovarian Follicle/metabolism; Proteasome Endopeptidase Complex/drug effects; Proteasome Endopeptidase Complex/metabolism; Survival Rate

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Autophagy / Boronic Acids / Apoptosis / Drosophila melanogaster / Endoplasmic Reticulum Stress / Proteasome Inhibitors Limits: Animals Language: En Journal: Cell Biol Toxicol Journal subject: TOXICOLOGIA Year: 2013 Document type: Article Affiliation country: Greece Country of publication: Switzerland

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