When inhibitors do not inhibit: critical evaluation of rational drug design targeting chorismate mutase from Mycobacterium tuberculosis.

Munack, Steffi; Leroux, Vincent; Roderer, Kathrin; Ökvist, Mats; van Eerde, André; Gundersen, Lise-Lotte; Krengel, Ute; Kast, Peter

Munack, Steffi; Leroux, Vincent; Roderer, Kathrin; Ökvist, Mats; van Eerde, André; Gundersen, Lise-Lotte; Krengel, Ute; Kast, Peter.

Affiliation

Munack S; University of Oslo, Department of Chemistry, P.âO. Box 1033, Blindern, NO-0315 Oslo, Norway.

Chem Biodivers ; 9(11): 2507-27, 2012 Nov.

Article in En | MEDLINE | ID: mdl-23161632

Subject(s)

Antitubercular Agents/chemistry; Antitubercular Agents/pharmacology; Chorismate Mutase/antagonists & inhibitors; Drug Design; Mycobacterium tuberculosis/enzymology; Chorismate Mutase/metabolism; Humans; Molecular Docking Simulation; Mycobacterium tuberculosis/drug effects; Structure-Activity Relationship; Tuberculosis/drug therapy; Tuberculosis/microbiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Chorismate Mutase / Mycobacterium tuberculosis / Antitubercular Agents Limits: Humans Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2012 Document type: Article Affiliation country: Norway

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