Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-&#954;B signaling pathways in LPS-treated rat cardiac microvascular endothelial cells.

He, Chang-Liang; Yi, Peng-Fei; Fan, Qiao-Jia; Shen, Hai-Qing; Jiang, Xiao-Lin; Qin, Qian-Qian; Song, Zhou; Zhang, Cui; Wu, Shuai-Cheng; Wei, Xu-Bin; Li, Ying-Lun; Fu, Ben-Dong

Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-κB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells.

He, Chang-Liang; Yi, Peng-Fei; Fan, Qiao-Jia; Shen, Hai-Qing; Jiang, Xiao-Lin; Qin, Qian-Qian; Song, Zhou; Zhang, Cui; Wu, Shuai-Cheng; Wei, Xu-Bin; Li, Ying-Lun; Fu, Ben-Dong.

Affiliation

He CL; Department of Pharmacy, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an, Sichuan, PR China.

Immunopharmacol Immunotoxicol ; 35(2): 215-24, 2013 Apr.

Article in En | MEDLINE | ID: mdl-23171279

Subject(s)

Anti-Inflammatory Agents/pharmacology; Anticoagulants/pharmacology; Drugs, Chinese Herbal/pharmacology; Endothelium, Vascular/drug effects; Inflammation/drug therapy; Lipopolysaccharides/pharmacology; Mitogen-Activated Protein Kinases/antagonists & inhibitors; NF-kappa B/antagonists & inhibitors; Animals; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Endothelium, Vascular/metabolism; Extracellular Signal-Regulated MAP Kinases/metabolism; Heart/drug effects; Inflammation/metabolism; Intercellular Adhesion Molecule-1/metabolism; JNK Mitogen-Activated Protein Kinases/metabolism; Kruppel-Like Transcription Factors/metabolism; Microvessels/drug effects; Microvessels/metabolism; Mitogen-Activated Protein Kinases/metabolism; NF-kappa B/metabolism; Phosphorylation/drug effects; Plasminogen Activator Inhibitor 1/metabolism; Rats; Rats, Wistar; Signal Transduction/drug effects; Thromboplastin/metabolism; Tumor Necrosis Factor-alpha/metabolism; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drugs, Chinese Herbal / Endothelium, Vascular / Lipopolysaccharides / NF-kappa B / Mitogen-Activated Protein Kinases / Inflammation / Anti-Inflammatory Agents / Anticoagulants Type of study: Prognostic_studies Limits: Animals Language: En Journal: Immunopharmacol Immunotoxicol Journal subject: ALERGIA E IMUNOLOGIA / FARMACOLOGIA / TOXICOLOGIA Year: 2013 Document type: Article Country of publication: United kingdom

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