Personalized medicine of esophageal cancer.

Wang, Lei; Yang, Hui-Yi; Zheng, Yong-Qing

Wang, Lei; Yang, Hui-Yi; Zheng, Yong-Qing.

Affiliation

Wang L; Department of Cardiothoracic Surgery, Hebei Medical University Forth Hospital, ShiJiaZhuang, Hebei, PR China.

J Cancer Res Ther ; 8(3): 343-7, 2012.

Article in En | MEDLINE | ID: mdl-23174712

ABSTRACT

The fatality rate of esophageal carcinomas is high in developing countries, making effective treatment desirable. Traditional treatment has now entered into the platform, and treatments based on the detection of biomarkers increasingly become a trend. This review presents several biomarkers of esophageal cancer, including chemotherapy-related biomarkers and targeted drug-related biomarkers, and the correlation of these biomarkers with drug response.

Subject(s)

Biomarkers, Tumor/genetics; Esophageal Neoplasms/drug therapy; Precision Medicine/methods; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; BRCA1 Protein/metabolism; DNA-Binding Proteins/metabolism; Developing Countries; Endonucleases/metabolism; ErbB Receptors/metabolism; Esophageal Neoplasms/genetics; Humans; Methylenetetrahydrofolate Reductase (NADPH2)/metabolism; Thymidylate Synthase/metabolism; Treatment Outcome; Tumor Suppressor Protein p53/metabolism; bcl-2-Associated X Protein/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Esophageal Neoplasms / Biomarkers, Tumor / Precision Medicine Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Cancer Res Ther Journal subject: NEOPLASIAS / TERAPEUTICA Year: 2012 Document type: Article Country of publication: India

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