Novel functions for Rab GTPases in multiple aspects of tumour progression.
Biochem Soc Trans
; 40(6): 1398-403, 2012 Dec 01.
Article
in En
| MEDLINE
| ID: mdl-23176488
ABSTRACT
Rab GTPases are master regulators of intracellular trafficking and, in recent years, their role in the control of different aspects of tumour progression has emerged. In the present review, we show that Rab GTPases are disregulated in many cancers and have central roles in tumour cell migration, invasion, proliferation, communication with stromal cells and the development of drug resistance. As a consequence, Rab proteins may be novel potential candidates for the development of anticancer drugs and, in this context, the preliminary results obtained with an inhibitor of Rab function are also discussed.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rab GTP-Binding Proteins
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Biochem Soc Trans
Year:
2012
Document type:
Article
Affiliation country:
United kingdom