Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia.

Mims, A; Walker, A R; Huang, X; Sun, J; Wang, H; Santhanam, R; Dorrance, A M; Walker, C; Hoellerbauer, P; Tarighat, S S; Chan, K K; Klisovic, R B; Perrotti, D; Caligiuri, M A; Byrd, J C; Chen, C-S; James Lee, L; Jacob, S; Mrózek, K; Bloomfield, C D; Blum, W; Garzon, R; Schwind, S; Marcucci, G

Mims, A; Walker, A R; Huang, X; Sun, J; Wang, H; Santhanam, R; Dorrance, A M; Walker, C; Hoellerbauer, P; Tarighat, S S; Chan, K K; Klisovic, R B; Perrotti, D; Caligiuri, M A; Byrd, J C; Chen, C-S; James Lee, L; Jacob, S; Mrózek, K; Bloomfield, C D; Blum, W; Garzon, R; Schwind, S; Marcucci, G.

Affiliation

Mims A; Department of Internal Medicine, The Ohio State University and The Ohio State University Comprehensive Cancer Center, Columbus, OH 43210, USA.

Leukemia ; 27(4): 871-8, 2013 Apr.

Article in En | MEDLINE | ID: mdl-23178755

Subject(s)

Azacitidine/analogs & derivatives; Epigenesis, Genetic; Histone Deacetylase Inhibitors/therapeutic use; Leukemia, Myeloid, Acute/drug therapy; MicroRNAs/genetics; Phenylbutyrates/therapeutic use; Animals; Azacitidine/therapeutic use; Blotting, Western; Cell Line, Tumor; Decitabine; Histone Deacetylases/metabolism; Humans; Leukemia, Myeloid, Acute/enzymology; Leukemia, Myeloid, Acute/genetics; Mice; Mice, Inbred NOD; Mice, SCID; Up-Regulation/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylbutyrates / Azacitidine / Leukemia, Myeloid, Acute / MicroRNAs / Epigenesis, Genetic / Histone Deacetylase Inhibitors Limits: Animals / Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2013 Document type: Article Affiliation country: United States Country of publication: United kingdom

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