Your browser doesn't support javascript.
loading
Delivery of ricin toxin a-chain by peptide-targeted mesoporous silica nanoparticle-supported lipid bilayers.
Epler, Katharine; Padilla, David; Phillips, Genevieve; Crowder, Peter; Castillo, Robert; Wilkinson, Dan; Wilkinson, Brian; Burgard, Cameron; Kalinich, Robin; Townson, Jason; Chackerian, Bryce; Willman, Cheryl; Peabody, David; Wharton, Walker; Brinker, C Jeffrey; Ashley, Carlee; Carnes, Eric.
Affiliation
  • Epler K; Center for Micro-Engineered Materials, University of New Mexico, 1 University of New Mexico, MSC 01-1120, Albuquerque, NM 87131, USA.
Adv Healthc Mater ; 1(3): 348-53, 2012 May.
Article in En | MEDLINE | ID: mdl-23184753
ABSTRACT
Mesoporous silica nanoparticle-supported lipid bilayers, or "protocells", exhibit a high loading capacity, enhanced colloidal stability, and peptide-directed, cell-specific uptake, making them especially well-suited for targeted delivery of protein toxins to cancer. Protocells loaded with ricin toxin A-chain (RTA) and targeted to hepatocellular carcinoma cause complete cell death at 30 pM of RTA without affecting the viability of control hepatocytes.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ricin / Carcinoma, Hepatocellular / Silicon Dioxide / Nanocapsules / Lipid Bilayers Limits: Humans Language: En Journal: Adv Healthc Mater Year: 2012 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ricin / Carcinoma, Hepatocellular / Silicon Dioxide / Nanocapsules / Lipid Bilayers Limits: Humans Language: En Journal: Adv Healthc Mater Year: 2012 Document type: Article Affiliation country: United States