The chemopreventive capacity of quercetin to induce programmed cell death in hepatocarcinogenesis.
Toxicol Pathol
; 41(6): 857-65, 2013 Aug.
Article
in En
| MEDLINE
| ID: mdl-23197198
ABSTRACT
In this study of chemoprevention in the rat modified resistant hepatocyte model, preneoplastic cells were diminished by >60% with quercetin pretreatment compared with those rats treated with N-Diethylnitrosamine (DEN) to induce liver cancer. This decrease occurred associated with an abolished DEN-induced lipid peroxidation as well as activation of caspase 9 and increased caspase 3, as determined by increased expression of cleaved caspase 3 and 9, but not cleaved caspase 8 and increased fragmentation of Poly (ADP-ribose) polymerase (PARP) inducing apoptosis of presumed genetically injured cells, when quercetin was administered before the initiation agent.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Precancerous Conditions
/
Quercetin
/
Apoptosis
/
Liver Neoplasms, Experimental
Limits:
Animals
Language:
En
Journal:
Toxicol Pathol
Year:
2013
Document type:
Article
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA