Encapsulated glucagon-like peptide-1-producing mesenchymal stem cells have a beneficial effect on failing pig hearts.

Wright, Elizabeth J; Farrell, Kelly A; Malik, Nadim; Kassem, Moustapha; Lewis, Andrew L; Wallrapp, Christine; Holt, Cathy M

Wright, Elizabeth J; Farrell, Kelly A; Malik, Nadim; Kassem, Moustapha; Lewis, Andrew L; Wallrapp, Christine; Holt, Cathy M.

Affiliation

Wright EJ; Institute for Cardiovascular Science, University of Manchester, Manchester, United Kingdom.

Stem Cells Transl Med ; 1(10): 759-69, 2012 Oct.

Article in En | MEDLINE | ID: mdl-23197668

Subject(s)

Cardiotonic Agents/metabolism; Glucagon-Like Peptide 1/metabolism; Heart Failure/therapy; Mesenchymal Stem Cells/metabolism; Myocardial Infarction/therapy; Alginates/metabolism; Anatomy, Cross-Sectional; Animals; Apoptosis; Cell Survival; Disease Models, Animal; Drug Delivery Systems/methods; Echocardiography; Glucuronic Acid/metabolism; Heart Failure/metabolism; Heart Failure/pathology; Hexuronic Acids/metabolism; Humans; In Situ Nick-End Labeling; Inflammation/therapy; Mesenchymal Stem Cell Transplantation/methods; Myocardial Infarction/metabolism; Myocardial Infarction/pathology; Myofibroblasts/metabolism; Myofibroblasts/pathology; Neovascularization, Pathologic/metabolism; Recombinant Fusion Proteins/metabolism; Sus scrofa; Ventricular Function, Left

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiotonic Agents / Glucagon-Like Peptide 1 / Mesenchymal Stem Cells / Heart Failure / Myocardial Infarction Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Stem Cells Transl Med Year: 2012 Document type: Article Affiliation country: United kingdom

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