Inhibitors of HIV-1 attachment. Part 9: an assessment of oral prodrug approaches to improve the plasma exposure of a tetrazole-containing derivative.

Yeung, Kap-Sun; Qiu, Zhilei; Yang, Zheng; Zadjura, Lisa; D'Arienzo, Celia J; Browning, Marc R; Hansel, Steven; Huang, Xiaohua Stella; Eggers, Betsy J; Riccardi, Keith; Lin, Ping-Fang; Meanwell, Nicholas A; Kadow, John F

Yeung, Kap-Sun; Qiu, Zhilei; Yang, Zheng; Zadjura, Lisa; D'Arienzo, Celia J; Browning, Marc R; Hansel, Steven; Huang, Xiaohua Stella; Eggers, Betsy J; Riccardi, Keith; Lin, Ping-Fang; Meanwell, Nicholas A; Kadow, John F.

Affiliation

Yeung KS; Bristol-Myers Squibb Research & Development, 5 Research Parkway, PO Box 5100, Wallingford, CT 06492, USA. kapsun.yeung@bms.com

Bioorg Med Chem Lett ; 23(1): 209-12, 2013 Jan 01.

Article in En | MEDLINE | ID: mdl-23200244

Subject(s)

Anti-HIV Agents/chemistry; HIV-1/metabolism; Prodrugs/chemistry; Tetrazoles/chemistry; Administration, Oral; Animals; Anti-HIV Agents/chemical synthesis; Anti-HIV Agents/pharmacokinetics; HIV-1/drug effects; Half-Life; Humans; Prodrugs/chemical synthesis; Prodrugs/pharmacokinetics; Rats; Structure-Activity Relationship; Tetrazoles/chemical synthesis; Tetrazoles/pharmacokinetics; Virus Attachment/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tetrazoles / Prodrugs / HIV-1 / Anti-HIV Agents Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Document type: Article Affiliation country: United States Country of publication: United kingdom

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