A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles.

Hoelting, Lisa; Scheinhardt, Benjamin; Bondarenko, Olesja; Schildknecht, Stefan; Kapitza, Marion; Tanavde, Vivek; Tan, Betty; Lee, Qian Yi; Mecking, Stefan; Leist, Marcel; Kadereit, Suzanne

Hoelting, Lisa; Scheinhardt, Benjamin; Bondarenko, Olesja; Schildknecht, Stefan; Kapitza, Marion; Tanavde, Vivek; Tan, Betty; Lee, Qian Yi; Mecking, Stefan; Leist, Marcel; Kadereit, Suzanne.

Affiliation

Hoelting L; Department of Biology, University of Konstanz, Universitaetsstrasse 10, 78457 Konstanz, Germany.

Arch Toxicol ; 87(4): 721-33, 2013 Apr.

Article in En | MEDLINE | ID: mdl-23203475

Subject(s)

Embryoid Bodies/drug effects; Embryonic Stem Cells/drug effects; Gene Expression Regulation, Developmental/drug effects; Nanoparticles/toxicity; Neurons/drug effects; Polyethylene/toxicity; Cell Culture Techniques/methods; Cell Differentiation/drug effects; Cell Line; Cell Survival/drug effects; Cells, Cultured; Cells, Immobilized/drug effects; Cells, Immobilized/metabolism; Cells, Immobilized/pathology; Embryoid Bodies/metabolism; Embryoid Bodies/pathology; Embryonic Stem Cells/metabolism; Embryonic Stem Cells/pathology; Gene Expression Profiling; Humans; Methylmercury Compounds/toxicity; Neurons/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Developmental / Polyethylene / Embryonic Stem Cells / Nanoparticles / Embryoid Bodies / Neurons Limits: Humans Language: En Journal: Arch Toxicol Year: 2013 Document type: Article Affiliation country: Germany Country of publication: Germany

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