Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign.

Sykes, Melissa L; Baell, Jonathan B; Kaiser, Marcel; Chatelain, Eric; Moawad, Sarah R; Ganame, Danny; Ioset, Jean-Robert; Avery, Vicky M

Sykes, Melissa L; Baell, Jonathan B; Kaiser, Marcel; Chatelain, Eric; Moawad, Sarah R; Ganame, Danny; Ioset, Jean-Robert; Avery, Vicky M.

Affiliation

Sykes ML; Discovery Biology, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan, Queensland, Australia.

PLoS Negl Trop Dis ; 6(11): e1896, 2012.

Article in En | MEDLINE | ID: mdl-23209849

Subject(s)

Drug Evaluation, Preclinical/methods; Trypanocidal Agents/isolation & purification; Trypanosoma brucei brucei/drug effects; Cell Line; Cell Survival/drug effects; High-Throughput Screening Assays/methods; Humans; Inhibitory Concentration 50; Microbial Viability/drug effects; Oxazines/metabolism; Staining and Labeling/methods; Trypanosoma brucei brucei/physiology; Xanthenes/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanocidal Agents / Trypanosoma brucei brucei / Drug Evaluation, Preclinical Type of study: Diagnostic_studies Limits: Humans Language: En Journal: PLoS Negl Trop Dis Journal subject: MEDICINA TROPICAL Year: 2012 Document type: Article Affiliation country: Australia Country of publication: United States

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