Silibinin inhibits the invasion of IL-6-stimulated colon cancer cells via selective JNK/AP-1/MMP-2 modulation in vitro.

Lin, Chiu-Mei; Chen, Yen-Hsu; Ma, Hon-Ping; Wang, Bao-Wei; Chiu, Jen-Hwey; Chua, Su-Kiat; Ong, Jiann-Ruey; Shyu, Kou-Gi

Lin, Chiu-Mei; Chen, Yen-Hsu; Ma, Hon-Ping; Wang, Bao-Wei; Chiu, Jen-Hwey; Chua, Su-Kiat; Ong, Jiann-Ruey; Shyu, Kou-Gi.

Affiliation

Lin CM; Department of Emergency Medicine, Shin Kong Wu Ho-Su Memorial Hospital , Taipei, Taiwan.

J Agric Food Chem ; 60(51): 12451-7, 2012 Dec 26.

Article in En | MEDLINE | ID: mdl-23210512

Subject(s)

Colonic Neoplasms/pathology; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors; Matrix Metalloproteinase 2/drug effects; Neoplasm Invasiveness/prevention & control; Silymarin/pharmacology; Transcription Factor AP-1/antagonists & inhibitors; Cell Line, Tumor; Cell Proliferation/drug effects; Humans; Interleukin-6/pharmacology; MAP Kinase Kinase 4; Matrix Metalloproteinase 2/analysis; Matrix Metalloproteinase 2/genetics; Matrix Metalloproteinase Inhibitors/pharmacology; Promoter Regions, Genetic/drug effects; Protein Kinase Inhibitors/pharmacology; Silybin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Silymarin / Colonic Neoplasms / Transcription Factor AP-1 / Matrix Metalloproteinase 2 / JNK Mitogen-Activated Protein Kinases / Neoplasm Invasiveness Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Agric Food Chem Year: 2012 Document type: Article Affiliation country: Taiwan

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