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Association between CCL2 haplotypes and knee osteoarthritis.
Hulin-Curtis, S L; Bidwell, J L; Perry, M J.
Affiliation
  • Hulin-Curtis SL; School of Veterinary Science, University of Bristol, Bristol, UK. Sarah.Curtis@bristol.ac.uk
Int J Immunogenet ; 40(4): 280-3, 2013 Aug.
Article in En | MEDLINE | ID: mdl-23211090
ABSTRACT
We examined five single nucleotide polymorphisms (SNPs) and reconstructed 5-locus haplotypes of the CCL2 gene, in knee osteoarthritis (OA) cases and in controls. The CCL2 rs2857657 variant (G) allele was observed more frequently in female knee OA cases than in controls. One haplotype (H5) was observed exclusively in the control group (f = 2.3%). Genetic variation in the CCL2 gene may be associated with knee OA.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chemokine CCL2 / Osteoarthritis, Knee Type of study: Risk_factors_studies Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: En Journal: Int J Immunogenet Journal subject: ALERGIA E IMUNOLOGIA / GENETICA Year: 2013 Document type: Article Affiliation country: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chemokine CCL2 / Osteoarthritis, Knee Type of study: Risk_factors_studies Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: En Journal: Int J Immunogenet Journal subject: ALERGIA E IMUNOLOGIA / GENETICA Year: 2013 Document type: Article Affiliation country: United kingdom