Downregulation of oxidative and nitrosative apoptotic signaling by L-carnitine in Ifosfamide-induced Fanconi syndrome rat model.

Sayed-Ahmed, Mohamed M; Hafez, Mohamed M; Aldelemy, Meshan Lafi; Aleisa, Abdulaziz M; Al-Rejaie, Salem S; Al-Hosaini, Khaled A; Al-Harbi, Naif O; Al-Harbi, Mohamed M; Al-Shabanah, Othman A

Sayed-Ahmed, Mohamed M; Hafez, Mohamed M; Aldelemy, Meshan Lafi; Aleisa, Abdulaziz M; Al-Rejaie, Salem S; Al-Hosaini, Khaled A; Al-Harbi, Naif O; Al-Harbi, Mohamed M; Al-Shabanah, Othman A.

Affiliation

Sayed-Ahmed MM; Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Oxid Med Cell Longev ; 2012: 696704, 2012.

Article in En | MEDLINE | ID: mdl-23213347

Subject(s)

Apoptosis/drug effects; Carnitine/pharmacology; Down-Regulation/drug effects; Fanconi Syndrome/metabolism; Fanconi Syndrome/pathology; Signal Transduction/drug effects; Animals; Blood Urea Nitrogen; Caspases/genetics; Caspases/metabolism; Catalase/genetics; Catalase/metabolism; Creatinine/blood; Disease Models, Animal; Fanconi Syndrome/blood; Gene Expression Regulation, Enzymologic/drug effects; Glutathione Peroxidase/genetics; Glutathione Peroxidase/metabolism; Ifosfamide/chemistry; Kidney/drug effects; Kidney/enzymology; Kidney/pathology; Male; Nitrates/metabolism; Nitric Oxide Synthase/genetics; Nitric Oxide Synthase/metabolism; Nitrites/metabolism; Nitrosation/drug effects; Oxidation-Reduction/drug effects; Rats; Rats, Wistar

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carnitine / Signal Transduction / Down-Regulation / Apoptosis / Fanconi Syndrome Limits: Animals Language: En Journal: Oxid Med Cell Longev Journal subject: METABOLISMO Year: 2012 Document type: Article Affiliation country: Saudi Arabia Country of publication: United States

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