Novel cinnoline-based inhibitors of LRRK2 kinase activity.

Garofalo, Albert W; Adler, Marc; Aubele, Danielle L; Bowers, Simeon; Franzini, Maurizio; Goldbach, Erich; Lorentzen, Colin; Neitz, R Jeffrey; Probst, Gary D; Quinn, Kevin P; Santiago, Pam; Sham, Hing L; Tam, Danny; Truong, Anh P; Ye, Xiaocong M; Ren, Zhao

Garofalo, Albert W; Adler, Marc; Aubele, Danielle L; Bowers, Simeon; Franzini, Maurizio; Goldbach, Erich; Lorentzen, Colin; Neitz, R Jeffrey; Probst, Gary D; Quinn, Kevin P; Santiago, Pam; Sham, Hing L; Tam, Danny; Truong, Anh P; Ye, Xiaocong M; Ren, Zhao.

Affiliation

Garofalo AW; Department of Medicinal Chemistry, Elan Pharmaceuticals, 180 Oyster Point Blvd, South San Francisco, CA 94080, United States. albert.garofalo@elan.com

Bioorg Med Chem Lett ; 23(1): 71-4, 2013 Jan 01.

Article in En | MEDLINE | ID: mdl-23219325

Subject(s)

Heterocyclic Compounds, 2-Ring/chemistry; Protein Kinase Inhibitors/chemistry; Protein Serine-Threonine Kinases/antagonists & inhibitors; Amides/chemical synthesis; Amides/chemistry; Amides/metabolism; Animals; Binding Sites; HEK293 Cells; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mice; Molecular Docking Simulation; Mutation; Protein Binding; Protein Kinase Inhibitors/chemical synthesis; Protein Kinase Inhibitors/metabolism; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; Protein Structure, Tertiary; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Serine-Threonine Kinases / Protein Kinase Inhibitors / Heterocyclic Compounds, 2-Ring Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Document type: Article Affiliation country: United States

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