CDR-H3 diversity is not required for antigen recognition by synthetic antibodies.

Persson, Helena; Ye, Wei; Wernimont, Amy; Adams, Jarrett J; Koide, Akiko; Koide, Shohei; Lam, Robert; Sidhu, Sachdev S

Persson, Helena; Ye, Wei; Wernimont, Amy; Adams, Jarrett J; Koide, Akiko; Koide, Shohei; Lam, Robert; Sidhu, Sachdev S.

Affiliation

Persson H; Banting and Best Department of Medical Research and Department of Molecular Genetics, The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario, Canada M5S 3E1.

J Mol Biol ; 425(4): 803-11, 2013 Feb 22.

Article in En | MEDLINE | ID: mdl-23219464

Subject(s)

Antibodies/immunology; Antigens/immunology; Complementarity Determining Regions/immunology; Immunoglobulin Heavy Chains/immunology; Amino Acid Sequence; Antibodies/chemistry; Antibodies/genetics; Complementarity Determining Regions/chemistry; Complementarity Determining Regions/genetics; Crystallography, X-Ray; Genetic Variation/immunology; Hydrogen Bonding; Immunoglobulin Fab Fragments/chemistry; Immunoglobulin Fab Fragments/genetics; Immunoglobulin Fab Fragments/immunology; Immunoglobulin Heavy Chains/chemistry; Immunoglobulin Heavy Chains/genetics; Models, Molecular; Molecular Sequence Data; Peptide Library; Protein Conformation; Sequence Homology, Amino Acid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin Heavy Chains / Complementarity Determining Regions / Antibodies / Antigens Type of study: Prognostic_studies Language: En Journal: J Mol Biol Year: 2013 Document type: Article Country of publication: Netherlands

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