Glutamate receptor 1 phosphorylation at serine 831 and 845 modulates seizure susceptibility and hippocampal hyperexcitability after early life seizures.

Rakhade, Sanjay N; Fitzgerald, Erin F; Klein, Peter M; Zhou, Chengwen; Sun, Hongyu; Huganir, Richard L; Hunganir, Richard L; Jensen, Frances E

Rakhade, Sanjay N; Fitzgerald, Erin F; Klein, Peter M; Zhou, Chengwen; Sun, Hongyu; Huganir, Richard L; Hunganir, Richard L; Jensen, Frances E.

Affiliation

Rakhade SN; Department of Neurology, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

J Neurosci ; 32(49): 17800-12, 2012 Dec 05.

Article in En | MEDLINE | ID: mdl-23223299

Subject(s)

Disease Susceptibility/metabolism; Hippocampus/metabolism; Hippocampus/physiology; Receptors, AMPA/metabolism; Receptors, AMPA/physiology; Seizures/metabolism; Animals; Animals, Newborn; Cerebral Cortex/metabolism; Disease Models, Animal; Disks Large Homolog 4 Protein; Excitatory Postsynaptic Potentials/drug effects; Excitatory Postsynaptic Potentials/physiology; Gene Knock-In Techniques/methods; Guanylate Kinases/biosynthesis; Humans; Hypoxia; Kainic Acid; Membrane Proteins/biosynthesis; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Phosphorylation; Receptors, AMPA/genetics; Seizures/chemically induced; Serine/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Seizures / Receptors, AMPA / Disease Susceptibility / Hippocampus Limits: Animals / Humans Language: En Journal: J Neurosci Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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