Genetic loss of murine pyrin, the Familial Mediterranean Fever protein, increases interleukin-1ß levels.

Hesker, Pamela R; Nguyen, MyTrang; Kovarova, Martina; Ting, Jenny P-Y; Koller, Beverly H

Hesker, Pamela R; Nguyen, MyTrang; Kovarova, Martina; Ting, Jenny P-Y; Koller, Beverly H.

Affiliation

Hesker PR; Curriculum of Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC, USA.

PLoS One ; 7(11): e51105, 2012.

Article in En | MEDLINE | ID: mdl-23226472

Subject(s)

Cytoskeletal Proteins/deficiency; Cytoskeletal Proteins/genetics; Interleukin-1beta/metabolism; Animals; Apoptosis Regulatory Proteins/metabolism; Calcium-Binding Proteins/metabolism; Carrier Proteins/metabolism; Caspase 1/metabolism; Cytoskeletal Proteins/metabolism; Inflammasomes/metabolism; Inflammation/pathology; Interleukin-1beta/biosynthesis; Lipopolysaccharides/pharmacology; Lymphocytes/pathology; Macrophages/drug effects; Macrophages/enzymology; Macrophages/pathology; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Pyrin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytoskeletal Proteins / Interleukin-1beta Type of study: Prognostic_studies Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United States

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