[Establishment of drug screening assay and pharmacodynamic evaluation method targeting influenza RNA polymerase].

Wang, Zhen; Wang, Xin; He, Zhen; Liu, Zhen-Long; Wei, Xiao-Lu; Yin, Xiao; Zhou, Jin-Ming; Li, Xiao-Yu; Zhang, Zhi-Zhen; Cen, Shan

Wang, Zhen; Wang, Xin; He, Zhen; Liu, Zhen-Long; Wei, Xiao-Lu; Yin, Xiao; Zhou, Jin-Ming; Li, Xiao-Yu; Zhang, Zhi-Zhen; Cen, Shan.

Affiliation

Wang Z; Department of lmmunology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Yao Xue Xue Bao ; 47(9): 1159-63, 2012 Sep.

Article in Zh | MEDLINE | ID: mdl-23227545

Subject(s)

Antiviral Agents; Drug Evaluation, Preclinical/methods; Genes, Reporter; Luciferases/metabolism; RNA-Dependent RNA Polymerase/antagonists & inhibitors; RNA-Dependent RNA Polymerase/metabolism; Amantadine/pharmacology; Antiviral Agents/isolation & purification; Antiviral Agents/pharmacology; HEK293 Cells; Humans; Alphainfluenzavirus/enzymology; Luciferases/genetics; Oseltamivir/pharmacology; Plasmids; Reproducibility of Results; Ribavirin/pharmacology; Sensitivity and Specificity; Transfection; Zanamivir/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / RNA-Dependent RNA Polymerase / Genes, Reporter / Drug Evaluation, Preclinical / Luciferases Type of study: Diagnostic_studies / Screening_studies Limits: Humans Language: Zh Journal: Yao Xue Xue Bao Year: 2012 Document type: Article Affiliation country: China Country of publication: China

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