[Calcium hypothesis of Alzheimer disease].
Usp Fiziol Nauk
; 43(4): 59-72, 2012.
Article
in Ru
| MEDLINE
| ID: mdl-23227722
ABSTRACT
Alzheimer's disease is the most common neurodegenerative disorder characterized by progressive memory and cognitive abilities loss. The etiology of Alzheimer's disease is poorly understood. In this regard, there is no effective treatment for the disease. Various hypotheses to explain the nature of the pathology of Alzheimer's disease led to the development of appropriate therapeutics. Despite of decades of research and clinical trials available therapeutics, at best, can only slow down the progression of the disease, but cannot cure it. This review dedicated to the one of modern hypotheses of Alzheimer's disease pathogenesis implied the impairment of calcium homeostasis as a key event for the development of neurodegenerative processes.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Calcium Channels
/
Calcium
/
Calcium Signaling
/
Presenilin-1
/
Alzheimer Disease
Limits:
Humans
Language:
Ru
Journal:
Usp Fiziol Nauk
Year:
2012
Document type:
Article