Metformin-mediated downregulation of p38 mitogen-activated protein kinase-dependent excision repair cross-complementing 1 decreases DNA repair capacity and sensitizes human lung cancer cells to paclitaxel.

Tseng, Sheng-Chieh; Huang, Yu-Ching; Chen, Huang-Jen; Chiu, Hsien-Chun; Huang, Yi-Jhen; Wo, Ting-Yu; Weng, Shao-Hsing; Lin, Yun-Wei

Tseng, Sheng-Chieh; Huang, Yu-Ching; Chen, Huang-Jen; Chiu, Hsien-Chun; Huang, Yi-Jhen; Wo, Ting-Yu; Weng, Shao-Hsing; Lin, Yun-Wei.

Affiliation

Tseng SC; Molecular Oncology Laboratory, Department of Biochemical Science and Technology, National Chiayi University, 300 Syuefu Road, Chiayi 600, Taiwan.

Biochem Pharmacol ; 85(4): 583-94, 2013 Feb 15.

Article in En | MEDLINE | ID: mdl-23228696

Subject(s)

DNA Repair/physiology; DNA-Binding Proteins/metabolism; Endonucleases/metabolism; Metformin/pharmacology; Paclitaxel/pharmacology; p38 Mitogen-Activated Protein Kinases/metabolism; Antineoplastic Agents/pharmacology; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival/drug effects; DNA-Binding Proteins/genetics; Dose-Response Relationship, Drug; Down-Regulation/drug effects; Endonucleases/genetics; Humans; Hypoglycemic Agents/pharmacology; Lung Neoplasms; Metformin/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Up-Regulation/drug effects

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Paclitaxel / P38 Mitogen-Activated Protein Kinases / DNA-Binding Proteins / DNA Repair / Endonucleases / Metformin Limits: Humans Language: En Journal: Biochem Pharmacol Year: 2013 Document type: Article Affiliation country: Taiwan Country of publication: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google