The membrane adaptor LAT is proteolytically cleaved following Fas engagement in a tyrosine phosphorylation-dependent fashion.

García-Blesa, Antonio; Klossowicz, Mikolaj; López-Osuna, Carmen; Martínez-Florensa, Mario; Malissen, Bernard; García-Cózar, Francisco J; Miazek, Arkadiusz; Aguado, Enrique

García-Blesa, Antonio; Klossowicz, Mikolaj; López-Osuna, Carmen; Martínez-Florensa, Mario; Malissen, Bernard; García-Cózar, Francisco J; Miazek, Arkadiusz; Aguado, Enrique.

Affiliation

García-Blesa A; Core Research Facility for Health Sciences, Department of Biomedicine, Biotechnology and Public Health (Immunology), University of C´adiz, c/ Dr MaraËnon, nâ¦ 3, C´adiz 1102, Spain.

Biochem J ; 450(3): 511-21, 2013 Mar 15.

Article in En | MEDLINE | ID: mdl-23240581

Subject(s)

Adaptor Proteins, Signal Transducing/metabolism; Membrane Proteins/metabolism; Protein-Tyrosine Kinases/metabolism; Proteolysis; fas Receptor/metabolism; Adaptor Proteins, Signal Transducing/chemistry; Adaptor Proteins, Signal Transducing/genetics; Animals; Cells, Cultured; HEK293 Cells; Humans; Jurkat Cells; Lymphocyte Activation/genetics; Lymphocyte Activation/physiology; Membrane Proteins/chemistry; Membrane Proteins/genetics; Mice; Mice, Inbred C57BL; Phosphorylation/genetics; Phosphorylation/physiology; T-Lymphocytes/immunology; T-Lymphocytes/metabolism; T-Lymphocytes/physiology; Tyrosine/metabolism; fas Receptor/genetics; fas Receptor/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Fas Receptor / Adaptor Proteins, Signal Transducing / Proteolysis / Membrane Proteins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Biochem J Year: 2013 Document type: Article Affiliation country: Spain Country of publication: United kingdom

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