Hyperoxic resuscitation after hypoxia-ischemia induces cerebral inflammation that is attenuated by tempol in a reporter mouse model with very young mice.

Døhlen, Gaute; Antal, Ellen-Ann; Castellheim, Albert; Thaulow, Erik; Kielland, Anders; Saugstad, Ola Didrik

Døhlen, Gaute; Antal, Ellen-Ann; Castellheim, Albert; Thaulow, Erik; Kielland, Anders; Saugstad, Ola Didrik.

Affiliation

Døhlen G; Department of Paediatric Research, University of Oslo and Oslo University Hospital, Oslo, Norway. gaute.dohlen@ous-hf.no

J Perinat Med ; 41(3): 251-7, 2013 May.

Article in En | MEDLINE | ID: mdl-23241583

Subject(s)

Asphyxia Neonatorum/therapy; Cyclic N-Oxides/therapeutic use; Encephalitis/drug therapy; Encephalitis/etiology; Hyperoxia/complications; Hypoxia-Ischemia, Brain/therapy; Resuscitation/adverse effects; Animals; Animals, Newborn; Antioxidants/therapeutic use; Asphyxia Neonatorum/complications; Brain/drug effects; Brain/metabolism; Brain/pathology; Cytokines/metabolism; Disease Models, Animal; Encephalitis/pathology; Free Radical Scavengers/therapeutic use; Genes, Reporter; Humans; Hypoxia-Ischemia, Brain/complications; Infant, Newborn; Luciferases/genetics; Mice; Mice, Transgenic; NF-kappa B/metabolism; Neuroprotective Agents/therapeutic use; Spin Labels

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asphyxia Neonatorum / Resuscitation / Hyperoxia / Hypoxia-Ischemia, Brain / Cyclic N-Oxides / Encephalitis Type of study: Guideline / Prognostic_studies Limits: Animals / Humans / Newborn Language: En Journal: J Perinat Med Year: 2013 Document type: Article Affiliation country: Norway Country of publication: Germany

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