Polyploidization without mitosis improves in vivo liver transduction with lentiviral vectors.

Pichard, Virginie; Couton, Dominique; Desdouets, Chantal; Ferry, Nicolas

Pichard, Virginie; Couton, Dominique; Desdouets, Chantal; Ferry, Nicolas.

Affiliation

Pichard V; INSERM UMR-S 948, Université de Nantes, CHU Hôtel Dieu, 44093 Nantes, France.

Hum Gene Ther ; 24(2): 143-51, 2013 Feb.

Article in En | MEDLINE | ID: mdl-23249390

Subject(s)

Genetic Vectors/metabolism; Lentivirus/metabolism; Liver/virology; Mitosis; Polyploidy; Recombination, Genetic; Animals; Cell Nucleus/virology; Cell Proliferation; Endoreduplication; Genetic Vectors/genetics; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; Hepatectomy; Hepatocytes/drug effects; Immunohistochemistry; Lentivirus/genetics; Liver/drug effects; Male; Moloney murine leukemia virus/genetics; Moloney murine leukemia virus/metabolism; Pyrrolizidine Alkaloids/pharmacology; Rats; Rats, Inbred F344; Transduction, Genetic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyploidy / Recombination, Genetic / Lentivirus / Genetic Vectors / Liver / Mitosis Limits: Animals Language: En Journal: Hum Gene Ther Journal subject: GENETICA MEDICA / TERAPEUTICA Year: 2013 Document type: Article Affiliation country: France Country of publication: United States

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