Design, synthesis, inhibition studies, and molecular modeling of pepstatin analogues addressing different secreted aspartic proteinases of Candida albicans.

Cadicamo, Cosimo D; Mortier, Jérémie; Wolber, Gerhard; Hell, Marie; Heinrich, Ina E; Michel, Dana; Semlin, Lydia; Berger, Ursula; Korting, Hans C; Höltje, Hans-Dieter; Koksch, Beate; Borelli, Claudia

Cadicamo, Cosimo D; Mortier, Jérémie; Wolber, Gerhard; Hell, Marie; Heinrich, Ina E; Michel, Dana; Semlin, Lydia; Berger, Ursula; Korting, Hans C; Höltje, Hans-Dieter; Koksch, Beate; Borelli, Claudia.

Affiliation

Cadicamo CD; Department of Organic Chemistry, Free University Berlin, Takustrasse 3, D-14195 Berlin, Germany.

Biochem Pharmacol ; 85(7): 881-7, 2013 Apr 01.

Article in En | MEDLINE | ID: mdl-23262278

Subject(s)

Antifungal Agents/chemistry; Aspartic Acid Endopeptidases/antagonists & inhibitors; Candida albicans/enzymology; Fungal Proteins/antagonists & inhibitors; Models, Molecular; Pepstatins/chemistry; Antifungal Agents/chemical synthesis; Aspartic Acid Endopeptidases/chemistry; Drug Design; Fungal Proteins/chemistry; Isoenzymes/antagonists & inhibitors; Isoenzymes/chemistry; Pepstatins/chemical synthesis; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pepstatins / Candida albicans / Fungal Proteins / Models, Molecular / Aspartic Acid Endopeptidases / Antifungal Agents Type of study: Prognostic_studies Language: En Journal: Biochem Pharmacol Year: 2013 Document type: Article Affiliation country: Germany Country of publication: United kingdom

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