Exaggerated translation causes synaptic and behavioural aberrations associated with autism.

Santini, Emanuela; Huynh, Thu N; MacAskill, Andrew F; Carter, Adam G; Pierre, Philippe; Ruggero, Davide; Kaphzan, Hanoch; Klann, Eric

Santini, Emanuela; Huynh, Thu N; MacAskill, Andrew F; Carter, Adam G; Pierre, Philippe; Ruggero, Davide; Kaphzan, Hanoch; Klann, Eric.

Affiliation

Santini E; Center for Neural Science, New York University, New York, New York 10003, USA.

Nature ; 493(7432): 411-5, 2013 Jan 17.

Article in En | MEDLINE | ID: mdl-23263185

Subject(s)

Autistic Disorder/genetics; Autistic Disorder/physiopathology; Eukaryotic Initiation Factor-4E/metabolism; Protein Biosynthesis; Synapses/metabolism; Synapses/pathology; Animals; Autistic Disorder/drug therapy; Autistic Disorder/pathology; Behavior, Animal/drug effects; Dendrites/metabolism; Dendrites/pathology; Eukaryotic Initiation Factor-4E/genetics; Eukaryotic Initiation Factor-4G/metabolism; Female; Hippocampus/metabolism; Hydrazones; Infusions, Intraventricular; Male; Mice; Mice, Transgenic; Neostriatum/metabolism; Neuronal Plasticity; Nitro Compounds/administration & dosage; Nitro Compounds/pharmacology; Nitro Compounds/therapeutic use; Prefrontal Cortex/metabolism; Protein Biosynthesis/drug effects; Protein Biosynthesis/genetics; RNA Caps/metabolism; Thiazoles/administration & dosage; Thiazoles/pharmacology; Thiazoles/therapeutic use

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autistic Disorder / Synapses / Protein Biosynthesis / Eukaryotic Initiation Factor-4E Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Nature Year: 2013 Document type: Article Affiliation country: United States Country of publication: United kingdom

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google