Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations.
Biol Lett
; 9(1): 20121049, 2013 Feb 23.
Article
in En
| MEDLINE
| ID: mdl-23269844
ABSTRACT
Human immunodeficiency virus can spread through target cells by transmission of cell-free virus or directly from cell-to-cell via formation of virological synapses. Although cell-to-cell transmission has been described as much more efficient than cell-free infection, the relative contribution of the two transmission pathways to virus growth during multiple rounds of replication remains poorly defined. Here, we fit a mathematical model to previously published and newly generated in vitro data, and determine that free-virus and synaptic transmission contribute approximately equally to the growth of the virus population.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Virus Replication
/
HIV Infections
/
HIV-1
Limits:
Humans
Language:
En
Journal:
Biol Lett
Journal subject:
BIOLOGIA
Year:
2013
Document type:
Article
Affiliation country:
United States