Gastric juice immunoreactive epidermal growth factor levels in patients with peptic ulcer disease.
Am J Gastroenterol
; 85(4): 404-7, 1990 Apr.
Article
in En
| MEDLINE
| ID: mdl-2327382
ABSTRACT
Immunoreactive epidermal growth factor (IR-EGF) was measured by a highly sensitive and specific radioimmunoassay in gastric juice samples obtained during endoscopy from 26 control subjects, 44 patients with duodenal ulcers, and 18 with benign gastric ulcers. In the active stage, the concentrations of the peptide were consistently reduced, compared with those found in control subjects (592.7 +/- 55.8 pg/ml), in both duodenal (262.6 +/- 21.4 pg/ml) and gastric ulcer patients (320.2 +/- 34.1 pg/ml) (p less than 0.001 and 0.01, respectively). Mean IR-EGF values distinctly lower than in the controls were still present in the gastric juice of patients with inactive duodenal ulcers (349.7 +/- 35.9 pg/ml; p less than 0.001), whereas no difference was observed in patients with healed gastric ulcers (502.2 +/- 132.3 pg/ml). Although these findings suggest a possible role for EGF deficiency in the pathogenesis of peptic ulcer disease, the pathophysiological significance of our results (if any) remains to be elucidated.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomach Ulcer
/
Duodenal Ulcer
/
Epidermal Growth Factor
/
Gastric Juice
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Am J Gastroenterol
Year:
1990
Document type:
Article
Affiliation country:
Italy