Endothelial MKK3 is a critical mediator of lethal murine endotoxemia and acute lung injury.

Mannam, Praveen; Zhang, Xuchen; Shan, Peiying; Zhang, Yi; Shinn, Amanda S; Zhang, Yitao; Lee, Patty J

Mannam, Praveen; Zhang, Xuchen; Shan, Peiying; Zhang, Yi; Shinn, Amanda S; Zhang, Yitao; Lee, Patty J.

Affiliation

Mannam P; Department of Internal Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT 06520-8057, USA.

J Immunol ; 190(3): 1264-75, 2013 Feb 01.

Article in En | MEDLINE | ID: mdl-23275604

Subject(s)

Acute Lung Injury/enzymology; Endothelial Cells/enzymology; Endotoxemia/enzymology; MAP Kinase Kinase 3/physiology; Acute Lung Injury/pathology; Acute Lung Injury/prevention & control; Animals; Apoptosis; Bronchoalveolar Lavage Fluid; Chemotaxis, Leukocyte/physiology; Disease Models, Animal; Endothelial Cells/pathology; Endotoxemia/pathology; Intercellular Adhesion Molecule-1/biosynthesis; Intercellular Adhesion Molecule-1/genetics; Lipopolysaccharides/toxicity; Lung/pathology; MAP Kinase Kinase 3/antagonists & inhibitors; MAP Kinase Kinase 3/deficiency; MAP Kinase Kinase 3/genetics; Mice; Mice, Knockout; Mitochondria/metabolism; NF-kappa B/metabolism; Neutrophil Activation; Peritonitis/chemically induced; Peritonitis/enzymology; RNA, Small Interfering/pharmacology; Radiation Chimera; Reactive Oxygen Species/metabolism; Sepsis/enzymology; Transcription Factor AP-1/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endotoxemia / Endothelial Cells / MAP Kinase Kinase 3 / Acute Lung Injury Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Immunol Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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