Identification of a novel Calotropis procera protein that can suppress tumor growth in breast cancer through the suppression of NF-&#954;B pathway.

Samy, Ramar Perumal; Rajendran, Peramaiyan; Li, Feng; Anandi, Narayana Moorthy; Stiles, Bradley G; Ignacimuthu, Savarimuthu; Sethi, Gautam; Chow, Vincent T K

Identification of a novel Calotropis procera protein that can suppress tumor growth in breast cancer through the suppression of NF-κB pathway.

Samy, Ramar Perumal; Rajendran, Peramaiyan; Li, Feng; Anandi, Narayana Moorthy; Stiles, Bradley G; Ignacimuthu, Savarimuthu; Sethi, Gautam; Chow, Vincent T K.

Affiliation

Samy RP; Infectious Diseases Programme, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore. rperumalsamy@yahoo.co.uk

PLoS One ; 7(12): e48514, 2012.

Article in En | MEDLINE | ID: mdl-23284617

Subject(s)

Antineoplastic Agents/pharmacology; Breast Neoplasms/pathology; Calotropis/chemistry; NF-kappa B/metabolism; Plant Proteins/pharmacology; Signal Transduction/drug effects; 9,10-Dimethyl-1,2-benzanthracene/toxicity; Animals; Antineoplastic Agents/isolation & purification; Antineoplastic Agents/therapeutic use; Apoptosis/drug effects; Breast Neoplasms/chemically induced; Breast Neoplasms/drug therapy; Breast Neoplasms/metabolism; Cell Proliferation/drug effects; Drug Screening Assays, Antitumor; Female; Gene Expression Regulation, Neoplastic/drug effects; Glutathione/metabolism; Humans; I-kappa B Kinase/metabolism; MCF-7 Cells; Phosphorylation/drug effects; Plant Proteins/isolation & purification; Plant Proteins/therapeutic use; Protein Transport/drug effects; Proteolysis/drug effects; Rats; Superoxide Dismutase/metabolism; Transcription Factor RelA/metabolism; Tumor Necrosis Factor-alpha/pharmacology; alpha-Tocopherol/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Proteins / Breast Neoplasms / Signal Transduction / NF-kappa B / Calotropis / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Document type: Article Affiliation country: Singapore Country of publication: United States

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