Positive selection in the chromosome 16 VKORC1 genomic region has contributed to the variability of anticoagulant response in humans.

Patillon, Blandine; Luisi, Pierre; Blanché, Hélène; Patin, Etienne; Cann, Howard M; Génin, Emmanuelle; Sabbagh, Audrey

Patillon, Blandine; Luisi, Pierre; Blanché, Hélène; Patin, Etienne; Cann, Howard M; Génin, Emmanuelle; Sabbagh, Audrey.

Affiliation

Patillon B; Inserm UMRS-946, Genetic Variability and Human Diseases, Institut Universitaire d'Hématologie, Université Paris Diderot, Paris, France. blandine.patillon@inserm.fr

PLoS One ; 7(12): e53049, 2012.

Article in En | MEDLINE | ID: mdl-23285254

Subject(s)

Anticoagulants/administration & dosage; Chromosomes, Human, Pair 16/genetics; Drug Resistance/genetics; Mixed Function Oxygenases/genetics; Selection, Genetic/physiology; 4-Hydroxycoumarins/administration & dosage; 4-Hydroxycoumarins/therapeutic use; Anticoagulants/therapeutic use; Biomarkers, Pharmacological/metabolism; Dose-Response Relationship, Drug; Female; Genetic Variation/physiology; Geography; Haplotypes; Humans; Indenes/administration & dosage; Indenes/therapeutic use; Individuality; Linkage Disequilibrium; Male; Polymorphism, Single Nucleotide/physiology; Vitamin K/administration & dosage; Vitamin K/antagonists & inhibitors; Vitamin K/therapeutic use; Vitamin K Epoxide Reductases

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Selection, Genetic / Chromosomes, Human, Pair 16 / Drug Resistance / Mixed Function Oxygenases / Anticoagulants Limits: Female / Humans / Male Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Document type: Article Affiliation country: France

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