Bioactive lipids metabolites in Amanita virosa.
Nat Prod Commun
; 7(11): 1495-8, 2012 Nov.
Article
in En
| MEDLINE
| ID: mdl-23285815
ABSTRACT
Thrombin is the key serine proteinase of the coagulation cascade and, therefore, a suitable target for inhibition of blood coagulation. An extract of Amanita virosa considerably inhibited thrombin (48%), but showed no inhibitory activity on trypsin. On the basis of inhibition selectivity between thrombin and trypsin and potency of thrombin inhibition, A. virosa constitutes a good starting material for the isolation of further compounds that are active against thrombin. Bioassay oriented fractionation of the extract of A. virosa led to the isolation of a complex mixture of triglycerides (TGs), monoacylglycerols (MAGs), free fatty acids (FAs) and ergosterol. The structures of the isolated lipids metabolites were determined on the basis of chemical and spectroscopic evidences.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antithrombins
/
Lipid Metabolism
/
Amanita
/
Lipids
Language:
En
Journal:
Nat Prod Commun
Journal subject:
BOTANICA
/
FARMACOLOGIA
/
QUIMICA
Year:
2012
Document type:
Article
Affiliation country:
Italy