Synthesis and anticonvulsant activity of new phenytoin derivatives.
Eur J Med Chem
; 60: 57-63, 2013 Feb.
Article
in En
| MEDLINE
| ID: mdl-23287051
ABSTRACT
Hybrids between phenytoin and thiosemicarbazide, 1,3,4-oxadiazole, 1,3,4-thiadiazole or 1,2,4-triazole were synthesized and tested for anticonvulsant activity. Preliminary anticonvulsant screening was performed using standard maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) screens in mice. The neurotoxicity was determined applying the rotarod test. Among these compounds, 4 and 5d showed the highest protection (80%) in the scPTZ test at a dose of 100 mg/kg, whereas the compound 5b displayed promising anticonvulsant effect in the MES model.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phenytoin
/
Seizures
/
Motor Activity
/
Anticonvulsants
Limits:
Animals
Language:
En
Journal:
Eur J Med Chem
Year:
2013
Document type:
Article
Affiliation country:
Egypt