Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling.

Yang, Wei-Lei; Jin, Guoxiang; Li, Chien-Feng; Jeong, Yun Seong; Moten, Asad; Xu, Dazhi; Feng, Zizhen; Chen, Wei; Cai, Zhen; Darnay, Bryant; Gu, Wei; Lin, Hui-Kuan

Yang, Wei-Lei; Jin, Guoxiang; Li, Chien-Feng; Jeong, Yun Seong; Moten, Asad; Xu, Dazhi; Feng, Zizhen; Chen, Wei; Cai, Zhen; Darnay, Bryant; Gu, Wei; Lin, Hui-Kuan.

Affiliation

Yang WL; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Sci Signal ; 6(257): ra3, 2013 Jan 08.

Article in En | MEDLINE | ID: mdl-23300340

Subject(s)

Intercellular Signaling Peptides and Proteins/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction/physiology; Tumor Suppressor Proteins/metabolism; Ubiquitination/physiology; Animals; Cell Membrane/metabolism; Cell Survival/genetics; Cell Transformation, Neoplastic/genetics; Deubiquitinating Enzyme CYLD; HEK293 Cells; Humans; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Mice; Mice, Knockout; Phosphorylation; Statistics, Nonparametric; Tumor Suppressor Proteins/deficiency; Tumor Suppressor Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Tumor Suppressor Proteins / Intercellular Signaling Peptides and Proteins / Proto-Oncogene Proteins c-akt / Ubiquitination Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2013 Document type: Article Affiliation country: United States

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