Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G.

Stanley, David J; Bartholomeeusen, Koen; Crosby, David C; Kim, Dong Young; Kwon, Eunju; Yen, Linda; Cartozo, Nathalie Caretta; Li, Ming; Jäger, Stefanie; Mason-Herr, Jeremy; Hayashi, Fumiaki; Yokoyama, Shigeyuki; Krogan, Nevan J; Harris, Reuben S; Peterlin, Boris Matija; Gross, John D

Stanley, David J; Bartholomeeusen, Koen; Crosby, David C; Kim, Dong Young; Kwon, Eunju; Yen, Linda; Cartozo, Nathalie Caretta; Li, Ming; Jäger, Stefanie; Mason-Herr, Jeremy; Hayashi, Fumiaki; Yokoyama, Shigeyuki; Krogan, Nevan J; Harris, Reuben S; Peterlin, Boris Matija; Gross, John D.

Affiliation

Stanley DJ; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America.

PLoS Pathog ; 8(12): e1003085, 2012 Dec.

Article in En | MEDLINE | ID: mdl-23300442

Subject(s)

Cullin Proteins/metabolism; Cytidine Deaminase/metabolism; HIV/immunology; Ubiquitin-Protein Ligases/metabolism; Ubiquitins/antagonists & inhibitors; APOBEC-3G Deaminase; CD4-Positive T-Lymphocytes/virology; Carrier Proteins/genetics; Carrier Proteins/metabolism; Cell Line; Cyclopentanes/pharmacology; HEK293 Cells; HIV/growth & development; HIV Infections/immunology; Humans; Magnetic Resonance Imaging; NEDD8 Protein; Pyrimidines/pharmacology; RNA Interference; RNA, Small Interfering; Ubiquitin-Protein Ligases/genetics; vif Gene Products, Human Immunodeficiency Virus/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ubiquitins / HIV / Cytidine Deaminase / Ubiquitin-Protein Ligases / Cullin Proteins Limits: Humans Language: En Journal: PLoS Pathog Year: 2012 Document type: Article Affiliation country: United States

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