Epitope dampening monotypic measles virus hemagglutinin glycoprotein results in resistance to cocktail of monoclonal antibodies.

Lech, Patrycja J; Tobin, Gregory J; Bushnell, Ruth; Gutschenritter, Emily; Pham, Linh D; Nace, Rebecca; Verhoeyen, Els; Cosset, François-Loïc; Muller, Claude P; Russell, Stephen J; Nara, Peter L

Lech, Patrycja J; Tobin, Gregory J; Bushnell, Ruth; Gutschenritter, Emily; Pham, Linh D; Nace, Rebecca; Verhoeyen, Els; Cosset, François-Loïc; Muller, Claude P; Russell, Stephen J; Nara, Peter L.

Affiliation

Lech PJ; Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America. Lech.patrycja@mayo.edu

PLoS One ; 8(1): e52306, 2013.

Article in En | MEDLINE | ID: mdl-23300970

Subject(s)

Antibodies, Monoclonal/immunology; Hemagglutinins, Viral/genetics; Measles Vaccine/immunology; Mutation; Adenoviridae/genetics; Animals; Antibodies, Neutralizing/immunology; CHO Cells; Chlorocebus aethiops; Cricetinae; Epitopes/genetics; Epitopes/immunology; Glycosylation; Hemagglutinins, Viral/immunology; Humans; Measles virus/genetics; Measles virus/immunology; Mice; Mice, Inbred BALB C; Mutagenesis, Site-Directed; Neutralization Tests; Plasmids; Protein Structure, Tertiary; Rabbits; Recombinant Proteins/immunology; Vero Cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Measles Vaccine / Hemagglutinins, Viral / Antibodies, Monoclonal / Mutation Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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