Endoglin deficiency in bone marrow is sufficient to cause cerebrovascular dysplasia in the adult mouse after vascular endothelial growth factor stimulation.

Choi, Eun-Jung; Walker, Espen J; Degos, Vincent; Jun, Kristine; Kuo, Robert; Pile-Spellman, John; Su, Hua; Young, William L

Choi, Eun-Jung; Walker, Espen J; Degos, Vincent; Jun, Kristine; Kuo, Robert; Pile-Spellman, John; Su, Hua; Young, William L.

Affiliation

Choi EJ; UCSF, Department of Anesthesia and Perioperative Care, San Francisco, CA 94110, USA.

Stroke ; 44(3): 795-8, 2013 Mar.

Article in En | MEDLINE | ID: mdl-23306322

Subject(s)

Bone Marrow/metabolism; Cerebrovascular Disorders/chemically induced; Intracellular Signaling Peptides and Proteins/deficiency; Vascular Endothelial Growth Factor A/adverse effects; Vascular Malformations/chemically induced; Animals; Bone Marrow Transplantation; Endoglin; Intracellular Signaling Peptides and Proteins/genetics; Intracellular Signaling Peptides and Proteins/metabolism; Macrophages/metabolism; Matrix Metalloproteinase 9/metabolism; Mice; Mice, Knockout; Models, Animal; Monocytes/metabolism; Receptor, Notch1/metabolism; Vascular Endothelial Growth Factor A/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Marrow / Cerebrovascular Disorders / Vascular Endothelial Growth Factor A / Intracellular Signaling Peptides and Proteins / Vascular Malformations Type of study: Prognostic_studies Limits: Animals Language: En Journal: Stroke Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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