Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes.

Diaper, Danielle C; Adachi, Yoshitsugu; Sutcliffe, Ben; Humphrey, Dickon M; Elliott, Christopher J H; Stepto, Alan; Ludlow, Zoe N; Vanden Broeck, Lies; Callaerts, Patrick; Dermaut, Bart; Al-Chalabi, Ammar; Shaw, Christopher E; Robinson, Iain M; Hirth, Frank

Diaper, Danielle C; Adachi, Yoshitsugu; Sutcliffe, Ben; Humphrey, Dickon M; Elliott, Christopher J H; Stepto, Alan; Ludlow, Zoe N; Vanden Broeck, Lies; Callaerts, Patrick; Dermaut, Bart; Al-Chalabi, Ammar; Shaw, Christopher E; Robinson, Iain M; Hirth, Frank.

Affiliation

Diaper DC; Department of Neuroscience, Institute of Psychiatry, MRC Centre for Neurodegeneration Research, King's College London, London SE5 8AF, UK.

Hum Mol Genet ; 22(8): 1539-57, 2013 Apr 15.

Article in En | MEDLINE | ID: mdl-23307927

Subject(s)

Amyotrophic Lateral Sclerosis/genetics; DNA-Binding Proteins/genetics; Drosophila melanogaster/genetics; Nerve Degeneration/genetics; Aging; Amyotrophic Lateral Sclerosis/pathology; Animals; Animals, Genetically Modified; DNA-Binding Proteins/metabolism; Disease Models, Animal; Frontotemporal Lobar Degeneration/genetics; Frontotemporal Lobar Degeneration/pathology; Larva; Nerve Degeneration/metabolism; Neuromuscular Junction/metabolism; Neuromuscular Junction/pathology; Neurons/metabolism; Neurons/pathology; Phenotype; Synaptic Transmission/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA-Binding Proteins / Drosophila melanogaster / Amyotrophic Lateral Sclerosis / Nerve Degeneration Limits: Animals Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2013 Document type: Article Affiliation country: United kingdom

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